Altitude sickness Drug May help Patients With Brain Tumour Live Longer

Altitude sickness Drug May help Patients With Brain Tumour Live Longer

Altitude Sickness Drug May Help Patients With Brain Tumour Live Longer(Represenational Image)

New Delhi: According to a recent study, a medication used to treat altitude sickness, glaucoma, epilepsy, heart failure and seizures may also help people suffering from fast-growing brain tumor known as glioblastoma, live longer.

Most glioblastoma patients with high level of a protein called BCL-3 were found to be unresponsive  to the beneficial effects of temozolomide (TMZ) -- a frequently used chemotherapy for the disease.
 

It was found that the protein shields cancer cells from TMZ damage by activating a protective enzyme known as carbonic anhydrase II.

According to the team, the altitude sickness drug, called acetazolamide, is a carbonic anhydrase inhibitor and can restore TMZ's ability to kill tumour cells. Thus, adding acetazolamide to TMZ may help those with glioblastoma to survive longer.

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Bahktiar Yamini, the study director from University of Chicago in Inllionis, US said," We tested this combination treatment strategy in several animal models. It cured some of them while others had a 30 to 40 per cent increase in survival time."

The study was published in the journal Science Translational Medicine, for which the team looked at BCL-3 level from previous human studies.

The study revealed that the patients with lower levels of BCL-3 who were treated with TMZ survived longer than patients who had high levels of this biomarker.

The author said," An important feature of predictors like BCL-3 is that they are informative. They can identify pathways to improve treatment response."

(Inputs From News Agency IANS)

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